According to entertainment site TMZ, Houston left the Bible behind in a rental home in 2011 and her former landlord put it up for sale.
The homeowner said Houston left many of her belongings in the beach house and her agent said he could keep them.
The Bible includes Houston's writing in it. She wrote the date of her marriage to Bobby Brown and the day her daughter, Bobbi Kristina, was born.
The owner sold the house in 2012 and threw away some items Houston left but said he felt the need to keep the Bible because it was "interesting" and could be a good investment.
The Bible is being sold through Moments in Time.
Houston was found dead in her bathroom in February 2012.
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