A commissioning service at the Anglican landmark marked the start of 'Tell, Serve, Give' - the latest in a series of evangelistic initiatives taking place across the North of England.
The Bishop of Whitby, Rt Rev Paul Ferguson told Premier: "We got all sorts of things happening.
"Some of them are quite church-based...but also we've got some things which are happening in perhaps rather less usual circumstances".
Launched by the Archbishop of York Dr John Sentamu in 2015, the first Northern Bishops' Mission was held in Sheffield Diocese. Similar events have since been held in various other northern dioceses.
Bishops from across the region taking part include Rt Rev Julian Henderson, the Bishop of Blackburn; Rt Rev Philip North, the Bishop of Burnley and Rt Rev Dr Jill Duff, the Bishop of Lancaster.
Bishop Julian said: "Preparations for 'Tell, Serve, Give' have been taking place for many months now and it is exciting now to be approaching the start of the mission.
"Everyone, including the Archbishop himself, will have packed schedules over the four days, with multiple opportunities to share the Gospel."
A prison visit, Zumba party, Prosecco and pizza evening, The Greatest Showman sing-a-long, street healing ministry and laser tag are among the hundreds of events planned.
The Archbishop of York, Dr John Sentamu said: "It is wonderful that the churches across the Diocese of Liverpool have committed to 'Tell, Serve, Give'.
"Churches are engaging in a huge variety of events as they seek to serve others and to show God's love in their local community.
"This will be a great weekend. I am looking forward to meeting many people across the Diocese and hope to see you at one of these fantastic events."
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