The charity has been on the ground working with teachers, pupils and communities to get schools up and running but has stressed that this process will take months.
More than 8,000 children have lost parents across West Africa due to the outbreak.
Alison Schafer is World Vision's Mental Health and Psychosocial Support Specialist in the capital Freetown. She has been advising the country's government about how to best approach the challenge of rebuilding a normal life for its people.
One of the challenges faced will be that children will not be using to studying and many will have been taken out of the school system to work or marry.
Many pupils will also be living in a different environment, especially those who have lost parents and may be with other relatives, away from their schools.
She told Premier: "World Vision has been providing things like social support training to teachers over the past 6 weeks in preparation for this day and there has been reports that teachers have felt a little bit overwhelmed with the task of coming back to school and teaching students who have been out of class for quite some time.
"I think that's the reality - I think children are going to perhaps be a little excited and hyperactive to begin with and then over a couple of weeks they may start to struggle with concentration, it's going to take some time for the children to settle back into the routine of studying in school and it will take time for the teachers and staff as well."
