Setting off from Asheville shortly before 11.30am (local time), a motorcade shall reach the Graham family home in Charlotte approximately three and a half hours later.
People wishing to view the procession are being invited to gather at recommended viewing areas along the route - one in Black Mountain and another in Charlotte.
Rev Billy Graham's body will lie in repose inside the Graham Family Homeplace on Monday and Tuesday, before his casket is taken to Washington D.C.
On Wednesday, the world-renowned preacher will become only the fourth person to lie in honour at the US Capitol government building.
Made of pine plywood, the coffin was crafted by inmates at Louisiana State Penitentiary whom Graham met on a visit in 2005.
Rev Billy Graham's body shall return to Charlotte on Thursday, ahead of a funeral service at the Billy Graham Library on Friday.
All living former US Presidents have been invited to the ceremony, while serving US leader Donald Trump is also due to attend.
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