The Pontiff will make the trip in September 2015 for the World Meeting of Families event.
It's Francis' first visit to the United States as pope and he becomes only the fourth reigning pontiff to visit the U.S.
Full details have yet to be released although it's expected the Holy Father will make the trip between September 25 and 27.
Local Archbishop Charles Chaput told CBS: "A hallmark of his papacy has been a keen focus on the many challenges that families face today globally. His charisma, presence and voice will electrify the gathering.
"As I've said many times before, I believe that the presence of the Holy Father will bring all of us - Catholic and non-Catholic alike - together in tremendously powerful, unifying and healing ways.
"We look forward to Pope Francis' arrival in Philadelphia next September and we will welcome him joyfully with open arms and prayerful hearts."