The Milwaukee Art Museum, in Wisconsin, has put the picture on display in a hope to start public discussions, according to the museum's director Dan Keegan.
The controversial art piece has received around 200 complaints and the Milwaukee Catholic Archbishop, Jerome Listecki, said the museum had been callous and the portrait was insulting in a blog last week, according to The Times of India.
Named 'Eggs Benedict' the work, made of around 17,000 condoms, will go on display in November.
The artist behind the work, Niki Johnson, said she made it two years ago as a response to Pope Benedict's position against the use of condoms.
The pontiff did relax his stance, saying condoms could be tolerated to stop the AIDS epidemic.
The museum says there has been more support than criticism: "We look forward to continuing the dialogue around this work and the role art plays in society," Keegan said.
