Dr Barry Morgan will take part in the "Grill the Archbishop" event this weekend as part of the Diocese of Llandaff's outreach programme.
A number of 16-24-year-olds are expected at St Mark's Church, Gabalfa, Cardiff, on Saturday Oct 17 to put their 'burning questions' about faith to the Archbishop.
Archbishop Barry said: "Some of the toughest questions I get asked come from young people - they have a knack of getting to the heart of things very quickly and have few qualms about challenging me.
"I'm very much looking forward to some heated debate."
It is organised by the Revd David Morris who is the vocations adviser for Llandaff Diocese.
Fr David said: "This is a great chance for youngsters from across the diocese to ask Archbishop Barry any questions about all sorts of things that may interest or trouble them - whether matters of faith or any topical issues affecting their lives.
"It's also a chance for young people in parishes and chaplaincies to meet with others their own age and encourage one another in faith through their fellowship. All are welcome."