There's some criticism the international community has not done enough to end the violence there which has displaced half the population and left more than 2 hundred thousand people dead.
Christian Aid have said it is "the largest humanitarian crisis since World War II" and that the violence "continues to escalate".
"The need for the international community to redouble its efforts to bring about a political solution could not be greater," Christian Aid said.
Half of the population in Syria have been forced to leave their homes with over 200,000 killed since the conflict started in 2011.
It is estimated that more than 12 million people inside Syria, and millions more refugees across Lebanon, Turkey, Iraq and Jordan are now in need of humanitarian assistance as a result of the conflict.
The UN has described it as 'the worst humanitarian crisis of our time'.
Frances Guy, Head of Middle East at Christian Aid said: "It's hard to ignore the relentless turmoil of the Middle East these days.
"But whilst all the UK headlines are dominated by the terror of the so-called Islamic State there is a danger we forget the millions of Syrians, Iraqis and Palestinians, who have been forced to flee their homes.
"Families are living in cramped and overcrowded conditions in countries struggling to cope with the overwhelming number of refugees. Inside Syria itself, millions of people have been displaced from their homes, trying to seek sanctuary in safer parts of the country.
"And then there are those who can't escape, trapped in besieged areas of Syria, men, women and children who are often used as pawns by one side or another in the fighting.
"In Yarmouk, a district of Damascus that was previously home to Syria's largest Palestinian refugee community, thousands of Palestinians are still under siege, with little or no access to food or water dozens have died of starvation. Siege is a medieval form of warfare which deprives people of humanity and should be roundly condemned."
Christian Aid said it had so far provided food, bedding, water clothes, shelter, healthcare and education to more than two million people.
Ms Guy added: "Thanks to the generosity of the British public Christian Aid has raised more than £2 million which has enabled our partners to provide support to communities in desperate need, and we will continue to expand our work to reach the most vulnerable."