Speaking in an interview with with Axios, Mr Pence said he had been made aware of the accusations made about him by Comedian Joy Behar.
"I'd like to laugh about it but I really can't," Mr Pence said in the live stream interview.
"I'm a believer like tens of millions in America today will have Ash on their foreheads to mark the beginning of Lent.
[An] overwhelming majority of Americans cherish their faith and we have... different types of faith in this country.
"But I have to tell you, to have ABC maintain a broadcast forum that compared Christianity to mental illness, is just wrong. And it's an insult not to me but to the vast majority of the American people who like me cherish their faith.
"My Christianity is the most important thing in my life. I try and start every day by opening the good book, my wife and I try and have a prayer together before I leave every morning. I can honestly tell you that my faith sustains me in all that I do."
Comedian Behar attacked Mr Pence's faith on 'The View' after a clip was played with former White House adviser Omarosa Manigault Newman claiming on a reality programme that "Jesus tells him to say things".
Behar said: "That's called mental illness... if I'm not correct, he's hearing voices."
Mr Pence disputed the accusation and said his faith wasn't "unusual".
"I think I'm a very typical American - whatever your faith traditions, people understand that," he added.
"I just think it demonstrates how out of touch some in the mainstream media are with the faith and values of the American people."
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