The Holy Father has been asked to say sorry for the crimes committed against them during European colonisation.
However some Native American leaders in the United States want him to go beyond that.
When the pontiff visits America in autumn Native American leaders want to ask the Pope to renounce a more than 500-year-old doctrine allowing European explorers to rule over them, according to Catholic Online.
Various leaders were planning a protest next month when the Pope is in Philadelphia, asking him to repeal the "Doctrine of Discovery" from 1452.
The document, signed by Pope Nicholas V, gave permission to conquer territory in the new world and declare war on all non-Christians, according to the Anti-Defamation League.
It has also been reported to have called for the enslavement of any Native Americans explorers might find - however the Catholic leaders throughout these centuries condemned the idea of people treating people as "animals".
Native Americans are unhappy because the Roman Catholic Church has never officially renounced the article.
During the Pope's July visit to Bolivia Pope Francis asked forgiveness from its indigenous peoples for "grave sins" committed by the Church, when the region was colonised by the West, according to the Independent.
Many Popes have stood firm against violence, however the Church has never apologised directly to the Native American people.
Around two million people are expected to attend Francis' Philadelphia address.
He is also scheduled to spend time in Washington D.C. and New York City during his trip.
