The call from Hull Youth for Christ (YFC) comes after a new study revealed 75 per cent of white working class boys are failing to secure five A*-C grades at secondary school.
Referring to deprivation in the local neighbourhood, Richard Newby from Hull YFC told Premier's News Hour: "There are parts of the city which really need the most support; they have the greatest concentration of issues and, yet, there is the greatest lack of Christian presense.
"The greatest lack of Christian interest in these communities should be of great concern to the Church."
Research published by the Sutton Trust found, in contrast, Chinese pupils from disadvantaged backgrounds were three times more likely to leave school with five good GCSEs than their white peers from the same socio-economic standing.
Sir Peter Lampl, chairman of the Sutton Trust and of the Education Endowment Foundation said: "It is worrying that there is such a disparity in the achievement of different ethnic groups at GCSE and particularly concerning that white working class boys and girls continue to perform so poorly."
Education is "at the heart" of the government's ambition to make the country one which "works for everyone", a Department for Education spokeswoman said.
She added: "This year alone we are investing £2.5 billion through the pupil premium to tackle educational inequality, and the attainment gap is narrowing at primary and secondary level through our measures to improve reading and maths skills."
Listen to Richard Newby from Hull Youth for Christ speaking with Premier's Aaron James: