He had been battling an aggressive form of cancer.
His church said he was "now spiritually healed and home with the Lord".
Wife Vanessa said: "I am confidant through my belief in God that my husband is now resting in a better place.
"Although his transition leaves a void for those of us who loved him dearly, we can celebrate and be happy for him, knowing he's at peace."
Besides his wife he is survived by four children and three grandchildren.
He rose to fame when, after becoming pastor of New Birth Missionary Baptist Church in 1987, he rose membership from 300 to 25,000.
The clergyman was known for his opposition to same sex marriage and homosexuality and he led a march against the legalisation in America.
In 2010 his ministry was almost destroyed when four men came forward to make allegations that he had forced them into sexual relations with him.
He denied the allegations. His church settled law suits out of court but the details of the claims are not known.
As the number of black Americans voting grew he was courted by politicians including Bill Clinton.
In 2006 his church hosted the funeral of civil rights activist Coretta Scott King.
Bishop Eddie delivered his final sermon at the church earlier this month.
His friend Matthew Ashimolowo spoke to Premier about the legacy of Bishop Eddie.
He said: "What you saw is what you got from him. He was one great man of humility. He had the capacity to enhance other people's gifts and make it happen. He brought modernity to the very church he was asked to pastor.
"Bishop Long gave towards the building of hospitals in Africa and towards the raising of black young people in the USA, giving them education."
