Other landmarks across the UK and around the world including churches, schools and universities are also set to join the annual Red Wednesday campaign.
Mervyn Thomas, the chief executive of Christians Solidarity Worldwide (CSW), one of the organisers, told Premier: "The red is [symbolic] for the blood of the martyrs.
"What we're trying to do on Red Wednesday is let the world known that we're standing with them in solidarity and in prayer."
Red Wednesday has been spearheaded by the Catholic charity Aid to the Church in Need (ACN), which estimates 61 per cent of the global population live in countries where religious freedoms are not respected.
Here are some of our great staff at Sutton celebrating #RedWednesday! Tag ACN in your photos! pic.twitter.com/3QD8mIKe0Q
— Aid to the Church (@acn_uk) November 27, 2018
Thousands of people are set to take part - some by expressing their solidarity on social media or wearing a red item of clothing.
Mervyn Thomas from CSW continued: "Red Wednesday is a time for us to remember those who are persecuted for their faith around the world - whether that's Christians or those of other faiths as well."
We can't wait to join with @acn_uk for another #RedWednesday: find out how you can get involved in making a stand for faith & freedom at https://t.co/yJRQbMoxu1 pic.twitter.com/qp1eFAvkVK
— CSWPress (@CSWPress) November 27, 2018
St Chad's Roman Catholic Cathedral in Birmingham, London's Southwark (Anglican) Cathedral, and St Mirin's Catholic Cathedral in Paisley are supporting the initiative.
Red Wednesday will also be marked at a host of educational institutions including Warwick University, York University and Kings College London.
Click here to listen to Premier's Rosie Wright speaking with Mervyn Thomas at CSW:
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