Dr Tom Catena, who treats up to 400 inpatients everyday in the Nuba Mountains, has been awarded a prize in recognition of his humanitarian work.
Clooney said Dr Catena, and all the Aurora Prize for Awakening Humanity finalists, are "modern day heroes" who have put themselves at risk.
The film star chairs the selection committee for the award, which is presented in Armenia to recognise an exceptional humanitarian worker.
Dr Catena said: "I draw my inspiration from the Nuba people. "And with my faith as my guide, I am honoured to continue to serve the world and make it a better place."
The Aurora Prize for Awakening Humanity marks the World War I era eight-year slaughter and allegd ethnic cleansing suffered by Armenians during the collapse of the Ottoman Empire.
Armenia believes approximately 1.5 million residents died in the pogroms however Turkey estimates deaths number in the thousands and it does not recognise the events as genocide.
Born in New York state, Dr Catena works with the Sudan Relief Fund and is on call 24 hours a day, seven day per week.
Hundreds of thousands of people have been affected by conflict between rebels and government forces in the Nuba Mountains.