Clergy at the Cathedral are worried about noise levels coming from Arundells, the stately home of former Sir Edward Heath.
He lived in the grade II-listed building from 1985 until his death in 2005.
The curators of Arundells want to host musical events in its two-acre grounds to raise money.
According to a plan to keep noise levels down submitted to Wiltshire Council, Arundells will hold up to 24 events a year in its ground ending by 10:15pm.
It has not put a specific limit on the number of people who may be attending these events, but suggests it is unlikely to ever be more than 150 people.
Revd Dame Sarah Mullally, Canon Treasurer of Salisbury Cathedral, told Premier: "Salisbury Cathedral enjoys a good relationship with Arundells, who are valued members of the Close.
"It is true that over a month ago, in response to a planning application to establish the Arundells gardens as an events venue, Salisbury Cathedral did raise some concerns.
"At the heart of those concerns was that fact that Arundells' gardens back onto a residential area and, in the interests of all Close residents, the Cathedral felt duty bound to ensure controls were put in place to manage traffic, frequency of events and noise levels.
"It's important to protect the residential environment of those living in the Close and the tranquillity of the Close for visitors.
"In general, the Cathedral tries to ensure that most events are held inside the Cathedral and any that take place outside are exceptional and inclusive in nature."