34 charities - including Oxfam and Save the Children - have signed a statement urging the international community to step up efforts to find a lasting solution.
Christian Aid's Head of Middle East, Janet Symes, said: "An immediate ceasefire is critical to stop innocent civilians paying the ultimate price.
Access to adequate healthcare, fuel and food is under serious threat; this destruction needs to end so that people can get the help they so desperately need.
"It is due to the failure of peace talks and lack of genuine effort to find a viable solution to the conflict that we are witnessing yet more innocent civilian casualties.
If the international community does not act with urgency to both stop the situation escalating and pursue an inclusive and comprehensive peace, then they will be condemning yet more innocent people to despair."
It's claimed 100 Palestinians have been killed in four days of Israeli air bombardments on Gaza.
Andy Walton is a former human rights adviser in Israel and Palestine.
He told Premier's Marcus Jones on the News Hour he's concerned the death toll is particularly one sided.
Hear more from him: