The Bible travelled to the moon on the Apollo 14 mission with astronauts Alan Shepard, Stuart Roosa and Edgar Mitchell.
The King James Bible is just 1.625 square inches and was given to the mission by the Apollo Prayer League.
Nate D. Sanders Auctions, which is selling the Bible, said in a statement: "The Apollo Prayer League's mission was to both pray for the safety of astronauts and help with humanitarian causes around the world."
Another miniature King James Bible that went to space on the Apollo 13 mission was sold at auction for £47,500 last year.
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