The site, which allows donors to give directly to those whose stories they are moved by, has raised more than £917,000 for people in need over the last eight years.
The site was founded in October 2009 in the York Diocese and is managed through a network of churches and local charities.
Dr John Sentamu said: "What Acts 435 is achieving is wonderful - imagine how much more could be done if we had 1,000 churches involved, not just 250. It works and it is easy to use. Donors are responding. Churches - let's seize the moment and use Acts 435 to contribute to the common good."
Many of those seeking assistance on the site are people in poverty. Some may need help fixing broken down washing machines or paying bills whereas others need help to cover travel costs to visit sick family members.
Jenny Herrera, Acts 435 Executive Director said: "It took 5 years to grant our 5,000th gift. The fact that we have reached 10,000 only two years later shows the way donors are responding to this cost-effective way of meeting real, specific needs of people living in poverty in the UK.
"It also shows how churches and charities have linked in with Acts 435 to bring support and blessing to people in their local communities."