The blaze at Clifton Boy's Home in the Westmoreland area of the Caribbean island on 15th January forced 29 youngsters to be temporarily rehoused at the nearby St John's Church.
The home's chairman, Rev Hartley Perrin, said: "Tears were seen on the faces of many who watched helplessly as the fire raged, consuming what had become a landmark and a place of refuge for so many for so long.
"An era had come to a tragic and sudden end."
The Clifton Boys' Home opened for orphaned or unwanted children in 1960 and is one of three children's homes managed by the Anglican Church in Jamaica.
Explaining why the home is so important, Carmen Bromley, General Secretary of the Jamaica Church Missionary Society, said: "We provide love, care and protection for the boys.
"We ensure that they are provided with a sound education to equip them to become useful citizens."
Essential items such as school uniforms have already been donated to the boys, who Mr Bromley said are doing "very well in their respective schools" despite the incident.
It is unclear how much will be needed to rebuild Clifton Boy's Home.
Rev Perrin added: "So it is the hope that the process of rebuilding and reconstruction will commence as soon as possible so that normality can again be realised."