They're accused of rigging government contracts and taking money intended for refugees and migrant centres.
The Holy See's warned society would break down if some people followed the law but others didn't.
Secretary of State Cardinal Pietro Parolin, said: "How can you not be worried?
"A society that does not pay attention to lawfulness is a society destined to give the strongest supremacy to trample over the weakest."
Thirty seven people were arrested last week on charges of extortion, corruption, money laundering and embezzlement.
One hundred politicians and businessmen are currently being investigated as well. One of them is a former Mayor of Rome, Gianni Alemanno.
