He has written an article with Ed Kessler, a high profile Jew and founder of the Woole Institute, in the Telegraph.
In it Prince Hassan condemns Islamic State saying he is "appalled... by the sickening attacks on our fellow human beings".
"We also know that to lose Christianity from its birthplace would be to destroy the richness of the tapestry of the Middle East and a hammer blow to our shared heritage," he said.
"The reality is that we are all one community, united by shared beliefs and history.
"But this is increasingly denied, with Islamic State in Iraq and the Levant, or Daesh as it is known in our region, taking the lead both in justifying and carrying out these attacks."
The pair say it is "abhorrent to us, as a Muslim and a Jew, to see Christianity and Christians under such savage assault across our region".
The letter adds: "Christianity has been part of the essential fabric of the Middle East for two thousand years. Far from being a Western import as some, incredibly, now seem to suggest, it was born here and exported as a gift to the rest of the world.
"Christian communities have been intrinsic to the development of Arab culture and civilisation."
Interfaith work is the only way to "end this dangerous slide towards hatred, self-destruction and fratricidal conflict," they write.
