Premier has joined 10 other Christian organisations in urging the Charity Commission to reject claims that faith-based groups holding traditional views on life, marriage and biological sex are "anti-rights".
In a letter coordinated by Alliance Defending Freedom (ADF) International, the organisations responded to an Amnesty International UK report that labelled 117 groups, including Premier, as "anti-rights organisations" and urged the Charity Commission to review the charitable status of some organisations it described as "gender critical".
Amnesty withdrew the report several days after publication, saying its "use of language does not reflect the position" of the charity.
However, the signatories argue the report contained "sweeping generalisations, allegations, and inaccuracies" and wrongly grouped together organisations with "vastly different missions and philosophical underpinnings".
The letter says the organisations include Christian charities, professional bodies, medical associations, organisations supporting women fleeing abuse or facing crisis pregnancies, and groups advocating for sex-based rights.
"In most cases, the only thing these organisations share is disagreement with Amnesty International UK's position on a handful of contested questions relating to the value of preborn human life, human sexuality, or the immutability of sex," the letter states.
The organisations also reject Amnesty's characterisation of their work as "anti-rights", arguing that many exist to defend freedoms including freedom of religion, conscience and expression.
They further accuse Amnesty International UK of repeatedly seeking to marginalise organisations holding traditional Christian beliefs on issues such as abortion, marriage and sexuality, pointing to previous Amnesty publications that criticised so-called "anti-rights" and "gender critical" groups.
The letter also challenges Amnesty's recommendation that the Charity Commission review the charitable status of some organisations and that funders strengthen due diligence to avoid supporting groups whose activities are said to undermine human rights protections.
The signatories argue those recommendations amount to "an explicit call to discriminate against our organisations by removing the mechanisms and resources that enable much of our work to continue".
While welcoming reports that the Charity Commission is examining Amnesty International UK's compliance with its legal and charitable obligations, the organisations urge the regulator to reaffirm that charities should be free to participate in public debate on contested moral issues without being portrayed as threats to human rights.
They also call on the Commission to recognise that Christian charities promoting religion and working on issues including the sanctity of life, marriage, family and biological sex "make a legitimate and valuable contribution to public life in England and Wales".
The letter is signed by representatives of ADF International, Affinity, Anglican Mainstream, CARE, the Catholic Medical Association, Christian Concern, the Christian Institute, Christian Medical Fellowship, the Evangelical Alliance, Lovewise and Premier Christian Media Trust.