The match will be played at Rome's Olympic Stadium and has been organised by former Inter Milan and Argentina captain Javier Zanetti.
The Catholic player has signed up others including Roberto Baggio, who is Buddhist, and Zinedine Zidane, who's Muslim.
Pope Francis is known for his love of football and it's hoped the match will help spread his message of peace between religions.
Javier Zanetti told Vatican Radio: "When I spoke with Pope Francis about this project, it was a big concern for us to do something for world peace.
"I think the fact that so many stars have joined in can help professional football support peace.
"Although the game is raising money for charitable purposes, the most important thing we want to do is spread the Pope's message of peace to the world."
Other players possibly making an appearance include Lionel Messi, Francesco Totti, and Gianluigi Buffon.