More than a hundred people gathered in central London to hand a list of almost 400 refugee children who are eligible to come to the UK from Calais to the Home Secretary.
Christians joined forced with Muslims, Jews, Hindus and people of no faith to demand action.
The protest took place a year to the day when harrowing pictures of three-year-old Alan Kurdi's tiny body on a Turkish beach sparked global outrage.
The toddler died alongside his brother, Galip, and their mother, Rehana, as they attempted to make the crossing from Bodrum to the Greek island of Kos at the hands of people smugglers.
The outcry following Alan's death led to widespread demands for more refugees to be settled in the UK.
Lieutenant Annette Wicks from the Salvation Army told Premier why she was at the protest: "One child died one year ago but actually he represents so many other children that are suffering right now in Calais and different places.
"Many of these children have a legal right to be here but there's a block in the system somewhere".
The list handed to Amber Rudd outlined the names of 387 children said to be eligible for asylum in the UK, including those with family links in the country and those who are to be cared for under a Government commitment to resettle more lone refugee children from Europe.
Bishop of Barking Peter Hill said: "It has been established that the UK has a legal obligation to these children, but, more to the point, this country has a moral obligation.
"As we mark the first anniversary of the death of Alan Kurdi, and remember all the other refugee children who have died trying to reach safety in the last year, I call on the Government to take a small humanitarian step in rescuing the children of Calais."
Fr Dominic Robinson spoke to the group outside the Home Office. He told Premier: "It's not a religious issue so much but it brings people who have a belief in common humanity together and that's why all of these faith leaders have come here today, to remember that little boy.
"There's a human issue and I'd like to invite [everyone] to reflect on that and to pray that our hearts might be turned towards these children in Calais who are in such need of our welcome and our hospitality in this country."
A Home Office spokesperson said: "Our priority is to protect the best interests of children who are in need of our help."
She added: "We are in active discussions with the UNHCR, other partner organisations and the Italian, Greek and French governments to strengthen and speed up mechanisms to identify, assess and transfer unaccompanied refugee children to the UK where this in their best interests.
"We continue to work closely with the French government to ensure that children in Calais with family links in the UK are identified, receive sufficient support and can access the Dublin family reunification process without delay."