Despite Jeremy Corbyn ordering with his party to vote with the government and approve a bill allowing the Prime Minister to begin formal Brexit negotiations, Stephen Pound, Dawn Butler, Rachael Maskell and Stephen Timms all voted against it.
Dawn Butler and Rachael Maskell both resigned from front-bench Labour positions in order to defy their leader.
Other Christian MPs who voted against the bill include the Liberal Democrat leader Tim Farron and member John Pugh, as well as several within the SNP who voted against the bill as a whole party.
Only one Conservative voted against the bill: party veteran and remainer Ken Clarke.
The bill passed easily in the end with 498 votes in favour versus 114 against. It happened after two days of marathon debates where over a hundred MPs had their say.
Rachael Maskell, a Christian and the Labour MP for York Central, said before the vote: "This is no protest.
"This is about the future of our country. It's about the future of jobs, it's about the future of our environment.
"It's really important that we continue to ensure that we fight this government all the way to make sure those things are secure."
The government's releasing a document outlining its plan for leaving the EU on Thursday.
