In a letter to be shared among churches this weekend, they encouraged constituents to register to vote, and consider the implications of their vote on issues such as the environment, rights for EU workers post-Brexit and euthanasia.
It said: "In 2015, Parliament voted overwhelmingly to protect society's most vulnerable people, by preventing the legalisation of assisted dying.
"Will your candidates uphold this decision? Will they support measures to promote the intrinsic value of life at every stage?"
The guidance urges believers to consider supporting a political candidate who will oppose assisted dying legislation and to remember the three million EU workers facing an "uncertain future".
In another reference to Brexit negotiations, it said: "To a great extent the outcome of this election will determine the approach taken on how this (leaving the European Union) is achieved, the priorities we pursue and the values we wish to treasure as our own in the UK and as partners with countries around the world.
"It will determine how we can heal divisions in our society, care for the vulnerable, how our public services are run and whether we can remain a united kingdom."
Other priorities they set out include electing candidates who will support the fight to end modern slavery and the right of parents to send their children to a Catholic school.
The bishop's letter goes on to say: "There are many other issues you will be considering. In all of them please bear in mind not only their impact on you and your family but also their impact on our wider world.
"The UK has a long and worthy tradition of generosity and justice. The values contained in these questions are fundamental to our way of life and the good of our society."
Commitments to "caring for the most vulnerable" in society, upholding current agreements to resettle 20,000 Syrian refugees and helping the world's poorest were also among concerns voiced by the bishops.
The letter concludes with a prayer: "Lord, grant us wisdom to act always with integrity, seeking the protection and flourishing of all, and building a society based on justice and peace."