Reports from the capital say the staff remain in a safe condition, but extended family members outside of the capital have been hit hard with a number of fatalities.
More than 6,000 people have died so far.
The Bible House has suffered substantial damage and most of the furniture and computers have been destroyed.
Grace Smith is the Support Relations Manager, she told Premier people are feeling hopeless at the moment.
"On the odd occasion when someone is rescued out of the rubble and they're alive, it's just an amazing sense of hope.
"But it's really, really difficult, it feels like they'll never be able to get back on their feet again and they don't know where to start."
She added that: "The Bible House is not standing anymore, it's got substantial damage and a lot of the houses around have also crumbled."
The Bible Society has begun to coordinate humanitarian relief efforts and has pledged £20,000 to help with the disaster.
It is giving food, blankets, mosquito nets, medicines and basic household supplies as well as replacing bibles and providing scriptures that deal with loss.
Listen to Premier's Desmond Busteed interview Grace Smith in Nepal, here: