The 6-point-4 magnitude quake struck close to the capital Tirana, on Tuesday.
40 people were killed and over 650 injured in the country's strongest tremor there since 1979.
Mission Without Borders (MWB) is an international organisation working with thousands of poverty stricken families across Eastern Europe.
The charity's Albanian office is based in Durres, one of the two cities most severely affected.
MWB has set up the campaign, Albania Earthquake Appeal to raise "much needed funds" to provide immediate support to families and communities.
MWB Country Director John Chamberlain told Premier how they are responding to the disaster: "We're distributing food parcels and clothing and blankets to those in need, we're preparing a truck to go as soon as we can with more supplies and we have rescue teams working to find people in the rubble."
Funds will also go towards the costs of repairing homes destroyed in the disaster.
Chamberlain is encouraging the Christian community to contribute to the appeal and pray for all those involved.
"Pray that more people will be found safe, there's a lot of people unaccounted for," he said.
"Pray for the country and the rescue teams and MWB. Pray for our partner churches that we can continue to do whatever we can to bring some help and support."
The European Commission has deployed rescue teams from Italy, Greece and Romania to help with the search efforts.
To date, 45 people have been recovered alive from the rubble and are being treated in hospital.
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