Having been a venue for the same festival in 2011, the Cathedral will this time prepare a stage for the musician and political activist Billy Bragg.
Before him, performing in the building will be post-punk band The Membranes with a full choir accompaniment.
The singer-songwriter King Creosote, indie band The Surfing Magazines and singer-songwriter Charlotte Hatherley will also perform there.
Wakefield Cathedral is one of many venues hosting the Long Divison festival, alongside St Austin's Roman Catholic church and Warehouse 23.
The sub Dean of Wakefield Cathedral, Canon Tony Macpherson said: "The Cathedral is proud to be part of this city-wide event which has grown year on year. We are a unique venue here in the heart of the city, open and welcoming to all, and are really looking forward to sharing our beautiful building with a new audience."
Roz Cochrane, Operations and Event coordinator at Wakefield Cathedral spoke to Premier about what they were expecting.
She said "we try and get as many people into the Cathedral as we can, who may not come for spiritual reasons but to remind that it's a space for everyone in the city."
"Obviously we have to balance things reasonably carefully in terms of our worship because we have worship seven days a week but by tomorrow the Cathedral will be returned to it's usual state ready for our four services."
Hear the full interview here:
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