Chorlton Arts Festival in Manchester will bring the atheist's 2006 book to the stage in May.
Dawkins said: "I'm thrilled to see The God Delusion come to life on stage for the first time and for the message of the book to be given a new lease of life in this exciting way, it's going to be a treat for audiences."
In his best-selling book, Dawkins argues that a supernatural creator almost certainly does not exist and if someone believes in a personal god, that person is delusional.
Thomas Moore has taken the lead of transforming the book into a theatrical performance.
He said: "The only way to describe the show is a light hearted journey through the sound reasoning that the book so brilliantly details.
"It's somewhere between an atheist support group and watching a great stand-up comedian. We hope that when people leave the show they feel changed."
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