Moderator Dr Charles McMullen is attending a state reception for the pontiff at Dublin Castle on 25th August.
The Presbyterian Church in Ireland is a large protestant denomination.
Dr McMullen will also be present at the World Meeting of Families in Croke Park in Dublin that evening, at the invitation of Catholic Archbishop Eamon Martin, which Pope Francis will also attend.
The event is held every three years to celebrate and think about the importance of families and marriage to society.
Dr McMullen said: "The visit of Pope Francis to Ireland for the World Meeting of Families will greatly enhance the affirmation of the place of the family at the heart of society and that has to be a good thing.
"I am personally very pleased that our church has been able to accept the invitation to the reception and I am looking forward to it.
"Should there be an opportunity to meet Pope Francis in Dublin Castle, I would also very much welcome that in the context of building good relations."
New #pcinews: Right Rev Dr Charles McMullen, @PCIModerator, has accepted an invitation from the Irish Government to the State reception it is holding for Pope Francis in Dublin Castle, on Saturday 25 August. You can read the full story at: https://t.co/NiJI5FST4F pic.twitter.com/96HCNUgUiE
— Presbyterian Church (@pciassembly) August 17, 2018
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