It is flying the Union flag from its tower will ring its bells as the Olympic and Paralympic parade passes the building in central Manchester.
Around 200,000 are expected to line the streets to see Britain's athletes, who won a record 214 medals in Rio.
Similar celebrations will be happening tomorrow in London's Trafalgar Square.
Heptathlete Jessica Ennis-Hill will make her first public appearance since announcing her retirement from athletics last week.
Speaking on Premier's News Hour the Dean of Manchester Cathedral, Very Rev Rogers Govender, said: "This is a very special occasion for our city.
"It's a great privilege to be hosting this parade on behalf of the nation, and so I think it's always great for the Church to be adding it's penny's worth, celebrating the joy.
"When we see ordinary members of our society achieving so well it really does inspire the nation, does it not?
"More importantly it inspires people who are disabled; it inspires our younger people, to really believe that they too can do it."
Listen to Premier's Aaron James speaking to Rogers Govender on the News Hour:
