'Apocalypse Slough' imagines the end of the world from the point of view of characters in the Berkshire town.
Producers of the show have described Father Jude's character as a man who is 'deeply moral', with a 'profound and passionate' faith.
They say his world will be turned upside down by news of the impending apocalypse, and he will find himself facing the greatest challenge of his life. One that will shake his faith, force him to question his vows, and bring him face to face with his past.
Rob Lowe said: "I've always been a fan of the kind of smart, ambitious and challenging filmmaking that comes from Sky and Working Title. This script and my character in particular, blew me away."
Other characters include an unhinged white supremacist played by Megan Mullally (Will and Grace), a mild mannered bank manager, a germ-phobic cyber-terrorist, an American 5 star general and a child who (possibly) rose from the dead.
British actress and BAFTA® Award nominee Pauline Quirke (Birds of a Feather), will take on the role of former nurse and tough-as-nails mum Paula.
Pauline Quirke said: "I was intrigued by the title then gripped by the actual scripts and storylines can't wait to get started!"
Filming on the series starts this month, at locations including London, South Africa, Malta and Slough.
Christian media critic Simon Carver speaking to Premier's Des Busteed on the News Hour: