Both squads have been invited to the Vatican a year on after the Church of England cricket team beat the Catholic Church in a game at Canterbury.
In September 2014 the Anglican XI beat the St Peter's XI by six wickets.
The Archbishop of Canterbury, the Most Revd Justin Welby has blessed the team at Lambeth Palace ahead of their departure later in the month.
The Canterbury Times has reported that during their time there, the team will meet with Pope Francis, as well as attend a special Mass at St Peter's.
Describing the 2014 charity match, Father Tony Currer, the captain of the Vatican XI, called the match "the biggest game of my life":
"If one of the boys gets hit in the face by a ball, it could set back ecumenical relations by decades!"
The Church of England team have a challenge on their hands as now many of the Vatican squad is made up of cricket fans studying in Rome, from Indian and Pakistan.
The teams will meet on October 24th.
