Speaking to Portuguese newspaper O Clarim, Cardinal Raymond Burke responded to Pope Francis' call in 2016 for Christians to apologise to homosexuals.
Cardinal Burke said: "I must say sincerely, even though I haven't read the words of the Pope, that I don't see why the Church ought to ask forgiveness for teaching the truth about sex and sexuality."
He told the publication that during his priesthood of more than 42 years, he had "always found priests very compassionate in meetings with people who have had this difficulty and have suffered from this condition".
Cardinal Burke highlighted in the interview that the Church's traditional teachings "affirm the truth of Christ".
He added: "We know that we are dealing with an abnormal condition: God has not created us to have sexual relations with people of the same sex.
"This is not a discrimination against persons.
"It is to affirm the truth of Christ, the truth of our faith."
The priest, who is the former Prefect of the Apostolic Signatura, also spoke about the "frightening decline of Christian culture" and the increase of "rampant secularism" in the United States.
He expalined: "I grew up during the 50s, when American society was marked by a Christian character, mostly Protestant but nevertheless faithful to the Christian identity.
"In those times, we knew about things that have become common today: the reality of abortion, of people who manifest homosexual tendencies, whose personal dignity we always respected, but we were formed to see these acts as absolutely unacceptable, against the nature that God had created for us."
