Theresa May was forced to refresh her team on Monday following the resignation of Damian Green after he admitted lying over pornography on his office computer.
Tory MP, Derek Thomas told Premier Christians should pray for politicians who lose their jobs.
He said: "What will happen today is some people will be promoted and will be very happy.
"It's quite a dramatic thing to lose your jobs and I think it will be good for Christians to pray for those that are sacked and lose jobs or are moved aside.
"I've seen how MPs who have put so much into working in a particular job or in a position to get a promotion... how they respond when it goes wrong and... it would be the right thing to pray for those that lose their jobs."
Former justice secretary David Lidington was appointed to Mr Green's old position of Minister for the Cabinet Office, but did not inherit the title of First Secretary of State.
Downing Street confirmed Chancellor Philip Hammond, Foreign Secretary Boris Johnson, Home Secretary Amber Rudd and Brexit Secretary David Davis are all keeping their current jobs.
But Northern Ireland Secretary James Brokenshire has resigned from the Cabinet on grounds of ill-health, just weeks ahead of major surgery for a lesion on his right lung.
The expected biggest reshuffle since Mrs May took office in 2016, also saw the wrong man announced as Tory party chair.
Chris Grayling was congratulated on the Conservatives' Twitter account before it was deleted and Brandon Lewis was confirmed as having the new role.
Listen to MP Derek Thomas speaking with Premier's Marcus Jones:
