The clergyman, who wants to remain anonymous, has said messing around with what many would consider a game could be horrifying.
His warning comes as Google lists the modern version of the Victorian-era 'spirit boards' as one of the top selling Christmas presents.
The priest, based in Dublin, told the Irish Independent: "It's easy to open up evil spirits but it's very hard to get rid of them.
"People, especially young people and teenagers who are likely to experiment with Ouija boards on a whim, can be very naive in thinking that they are only contacting the departed souls of loved-ones when they attempt to communicate with the dead using the boards.
"It's like going to some parts of Africa and saying I'm personally immune to Ebola. But it does leave people open to all kinds of spiritual dangers. People don't intend any spiritual harm by it, but we live in a spiritual realm and you have no way to control what may impinge on you."
He told the newspaper that evil spirits and demons can pretend to be loved ones as a way to gain possession of the user, "people don't realise they can get infected," he said.