It's believed a group from the 100 Syrians arriving in Glasgow on Tuesday night will be resettled on the picturesque island off the west coast of Scotland.
Several more special flights will arrive at airports around Britain in the coming months as part of a programme to take 20,000 refugees in by 2020.
New arrivals will be given a five-year visa allowing them to remain in the country, after which they will be able to apply for leave to remain.
St Andrew's Church hall on Bute is preparing to be a base for the refugees and offer support and supplies to help people start a new life.
Other churches on the island are also coming together to help.
Revd Owain Jones from the United Church in Rothesay told Premier's News Hour the refugees will be warmly welcomed.
"We've got space for people," he said, "they're human beings who are in need and who will fit into our community".
But he admitted there was a "degree of mixed feeling" given the terror attacks in Paris.
"I'd say the overwhelming reaction is very human even among people who have reservations.
"I think the global situation makes some people fearful, but the vast majority of people see this in the first place as a human emergency."
Downing Street refused to specify how many refugees were arriving today but said they had undergone "rigorous" security checks before boarding the plane.
At the weekend Home Secretary Theresa May said those who arrive in the UK from the region will have been thoroughly screened to ensure they do not pose a terrorist threat.
She said multiple checks are in place for those earmarked for relocation in Britain.
"There are two levels of screening that take place," she told BBC1's Andrew Marr Show.
"First of all, we are taking people directly from the camps. We are working with UNHCR - UNHCR take biometrics, they look at documents, they interview people, they do their own process of screening against issues like war crimes and serious criminality.
"Then there is a further check that is done once people are referred to the UK. The Home Office then undertakes further checks, further biometrics are taken."
Revd Owain Jones speaking to Premier's Marcus Jones:
