The post has laid empty since 1572 and has been filled again by Rev Canon Mark Tanner.
His job's been created in response to the retirement of Newcastle Diocese's assistant bishop Rt Rev Frank White.
Downing Street confirmed the news this morning and said the Queen had approved the nomination of Rev Canon Tanner.
The 45-year-old was ordained in 1998 and took up his first post at St Mary's Church near Birkenhead.
He serves on the Church of England's General Synod and is married to Lindsay with two teenage children.
He said: "It's a huge honour to be nominated as the next Bishop of Berwick, and I am thrilled to be moving to the Diocese of Newcastle.
"We love Northumberland, and I am very much looking forward to working with Bishop Christine and the team. There is nothing as wonderful as seeing individuals and communities grow in the life and freedom found in Christ."
Bishop of Newcastle, Rt Rev Christine Hardman, said: "I am delighted that Mark has accepted the invitation to be the Bishop of Berwick.
"I know that he will be a great blessing to the whole Diocese of Newcastle. He brings a wonderful range of experience in ministry and is a person of great insight, integrity and warmth.
"I am looking forward tremendously to our work together as we face the exciting challenge in this Diocese of growing the Church and sharing the depth of God's love in ways that bring hope and touch the reality of people's lives."
Canon Tanner will be consecrated a bishop by the Archbishop of York, Dr John Sentamu, in a service at York Minster on October 18.