The service on Sunday will be open to people of all faiths and none and will take place at St Thomas Church in the city centre just metres from where Sergei and Yulia Skripal were found.
Church leaders said they want to symbolically reclaim the city for the common good.
Rev Kelvin Inglis, Rector of St Thomas' Church, said: "The service will bring together city leaders and representatives, members of the business community and local people, together with leaders and members of the emergency and public services.
"We shall gather in thanksgiving for the work of the services involved, in prayer for those affected, and in looking forward to the future of our fine city.
"At the conclusion of the service, we shall go in procession to near the site where the Skripals were found for a ceremony symbolically to 'reclaim' our city for the common good.
"Our service will include hymns and prayers from both Russia and this country, as well as from the Christian Bible that been the grounding of both of our cultures. While we feel rightly outraged at this act, I have seen no sense that in the city wishes anything but friendship with the Russian people and better relations between our governments."
The Skripals were found unconscious on a bench on 4th March.
It's claimed they came in contact with military-grade nerve agent Novichok.
The UK has accused Russia of being behind the attack.
Yulia Skripal has now been released from hospital while her father's health is said to be improving.
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