The film is the sequel to Fifty Shades of Grey and is based on the erotic novels by EL James.
Set for general release on Valentine's Day, campaigners argue that the message of the film romanticises domestic violence and abuse.
Natalie Collins, the founder of The Fifty Shades is Domestic Abuse campaign told Premier: "It adds yet another layer of normalising to abusive behaviour and that can't be a good thing to our society. And yes it's great if people can separate the fact from the fiction but actually when the fiction is talking about something that affects 25 per cent of women I don't think we can separate it."
The campaign will be using the hashtag #dontbeblindtoabuse in protesting at the premiere and on social media.
Campaigners are also encouraging people to boycott the film and instead donate the money they would have spent on a cinema ticket to Women's Aid.
Collins said that we shouldn't get swept up in the popularity of the series: "View it critically and not just to accept it just because the hype is saying it's romantic because it's released on Valentine's Day. Engage critically and think 'Would I be happy if someone treated me like this?'"
The protesters will meet at O'Neills on Wardour Street, Soho at 3.30pm today before heading to the premiere.
Fifty Shades of Grey made $547.4 million at the box office when it was released in 2015. The books have sold 125 million copies worldwide.