The season finale of the show attracted more than 9.2 million viewers on Sunday evening, reportedly making it the most-watched episode since the third series.
Based in the East End of London during the late 1950s and early 1960s, the drama was based on the memoirs of former-nurse, Jennifer Worth.
Starring Vanessa Regrave, Judy Parfitt and Miranda Hart much of 'Call The Midwife' is set at a nursing convent in the deprived district of Poplar.
Writing the Daily Express, Ann Widdecombe said she was "saddened that Call The Midwife has ended."
The former-Conservative Party politician added: "It is rare these days for TV to treat the Christian faith sympathetically and I shall miss the nuns of Nonnatus House floating into my lounge every Sunday evening with their prayers and their mission.
Ann Widdecombe will be performing herself this Christmas when she stars as the Fair Godmother alongside Basil Brush in a Cinderella pantomime being staged at the Royal Theatre in Windsor.